From U.S. 20 (Illinois): Turn North (right) onto Locust Street at the stoplights coming off of the Julien Dubuque Bridge.  Proceed for 10 blocks to the stop light and turn East (right) onto W 9th St. At stop light turn North (left) at Main Street , proceed two blocks Cotton Cabin is on the left hand side of the street at 1075 Main Street.

From U.S. 20 (Iowa): Turn North (left) onto Locust Street at the stoplights facing the Julien Dubuque Bridge (at the base of long downhill drive). Proceed for 10 blocks to the stop light and turn East (right) onto W 9th St. At stop light turn North (left) at Main Street , proceed two blocks Cotton Cabin is on the left hand side of the street at 1075 Main Street.

From Hwy 52 North: Hwy 52 becomes Central Ave. in downtown Dubuque. Follow Central to 11th Street. Turn West (right) at 11th. Proceed for two blocks then at the second stop sign turn South (left) at Main Street; Cotton Cabin is on the right hand side of the street at 1075 Main Street.

From Hwy 52 South: Take the Locust Street/Downtown Exit. Proceed for 12 blocks to the stop light and turn East (right) onto W 9th St. At stop light turn North (left) at Main Street , proceed two blocks Cotton Cabin is on the left hand side of the street at 1075 Main Street.
 
From Hwy 61 (Iowa): Take the Locust Street/Downtown Exit. Proceed for 12 blocks to the stop light and turn East (right) onto W 9th St. At stop light turn North (left) at Main Street , proceed two blocks Cotton Cabin is on the left hand side of the street at 1075 Main Street.

From Hwy 61 (Wisconsin): Exit West (right) at 11^th Street exit. Turn West (right at the stop sign). Proceed for seven blocks at the stop sign turn South (left) onto Main Street, Cotton Cabin is on the right hand side of the street at 1075 Main Street